Ethyl pyruvate decreases HMGB1 release and ameliorates murine colitis
نویسندگان
چکیده
منابع مشابه
Sequestering HMGB1 via DNA-Conjugated Beads Ameliorates Murine Colitis
Inflammatory bowel disease (IBD) is chronic inflammation of the gastrointestinal tract that affects millions of people worldwide. Although the etiology of IBD is not clear, it is known that products from stressed cells and enteric microbes promote intestinal inflammation. High mobility group box 1 (HMGB1), originally identified as a nuclear DNA binding protein, is a cytokine-like protein mediat...
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Retinal pathogenic angiogenesis in the eyes is a causative factor in retinopathy of prematurity, diabetic retinopathy, and age-related macular degeneration. This study was designed to examine the pathogenic role of the high-mobility group box-1 (HMGB1) protein and the inhibitory effect of ethyl pyruvate (EP), a well-known antioxidant substance, in retinal pathogenic angiogenesis in mice with ox...
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BACKGROUND The treatment of patients with multiple trauma including blunt chest/thoracic trauma (TxT) and hemorrhagic shock (H) is still challenging. Numerous studies show detrimental consequences of TxT and HS resulting in strong inflammatory changes, organ injury and mortality. Additionally, the reperfusion (R) phase plays a key role in triggering inflammation and worsening outcome. Ethyl pyr...
متن کاملEthyl Pyruvate Ameliorates The Damage Induced by Cyclophosphamide on Adult Mice Testes
Objective Cyclophosphamide (CP) is a chemotherapy drug which causes deleterious effects on testicular tissue and increases free radicals in the body. The aim of this study is to investigate the protective effects of ethyl pyruvate (EP) on testicular improvement in CP treated animals. MaterialsAndMethods In this experimental study, 15 male mice (6-8 weeks) were divided into 3 groups. The control...
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ژورنال
عنوان ژورنال: Journal of Leukocyte Biology
سال: 2009
ISSN: 0741-5400
DOI: 10.1189/jlb.1008662